Polynucleotides (PDRN)

Benefits of Polynucleotide Skin Rejuvenation

Polynucleotide injections may be considered for people looking to improve the appearance of their skin without the primary aim of adding facial volume.

Potential benefits include:

• Improved skin texture: Support for smoother-looking skin and a more refined appearance.
• Skin hydration: Improvements in skin hydration and overall skin quality have been reported in clinical studies.
• Fine line reduction: Potential improvement in the appearance of fine lines and early wrinkles.
• Skin elasticity: Support for skin firmness and elasticity.
• Under-eye rejuvenation: A possible treatment option for selected concerns involving fine lines and crepey skin around the eyes.
• Natural-looking results: Gradual improvements in skin quality rather than an immediate change in facial contours.

Individual results are not guaranteed, and the scientific evidence is still developing.

Which Areas Can Polynucleotides Treat?

Polynucleotide injections may be used in selected areas where skin quality, texture and elasticity are a concern.

• Under-Eye Polynucleotide Treatment: The delicate skin around the eyes can develop fine lines, crepiness and visible signs of ageing. Under-eye polynucleotide treatment may be considered to improve the appearance of fine lines and skin texture in appropriately selected patients. It is not a replacement for treatments designed to restore significant volume or correct pronounced tear-trough hollows. A consultation is essential to determine whether this treatment is appropriate for the eye area.
• Face and Cheeks: Polynucleotide injections may be used on selected areas of the face and cheeks to address fine lines and early wrinkles, uneven skin texture, dull or tired-looking skin, changes in skin elasticity, and visible signs of skin ageing. The treatment aims to improve skin quality without the principal purpose of reshaping the face.
• Neck: The neck can develop fine lines, uneven texture and reduced elasticity as the skin ages. Polynucleotide treatment may be considered to support improvements in the appearance of these concerns.
• Décolletage: The décolletage is frequently exposed to sunlight and may develop fine lines, uneven texture and other visible signs of ageing. Polynucleotides may be an option for selected patients seeking to improve skin quality in this area.
• Hands: Ageing hands can develop changes in skin texture, fine lines and reduced elasticity. Depending on the product and the individual's needs, polynucleotide treatment may be considered as part of a personalised skin rejuvenation plan.

What Happens During a Polynucleotide Treatment?

At YourHealthFirst Clinic, your treatment begins with an individual assessment and consultation to establish your suitability and discuss your desired outcomes.

• Step 1: Initial consultation: Your practitioner will assess your skin, discuss your concerns and review your medical history, allergies, previous aesthetic treatments and treatment goals. A personalised plan will be recommended if appropriate.
• Step 2: Skin preparation: The treatment area will be cleansed and prepared. Depending on the product and treatment protocol, a topical anaesthetic may be offered to help improve comfort during the procedure.
• Step 3: Polynucleotide injections: Small quantities of the selected polynucleotide product are injected into the appropriate skin layer using a fine needle or another suitable injection technique. The injection method and treatment points depend on the area being treated and the product used.
• Step 4: Aftercare and review: You will receive personalised aftercare instructions, including advice on managing temporary swelling, redness or bruising. A follow-up appointment may be arranged to assess your progress and discuss any further treatment.

How Many Polynucleotide Sessions Will I Need?

Polynucleotide treatment is often delivered as a course of sessions rather than a single appointment.

Some treatment protocols recommend approximately three to four sessions, usually spaced two to four weeks apart. However, the recommended number of sessions and the interval between treatments depend on the selected product, treatment area and individual skin assessment.

Improvements may develop gradually over several weeks. Some people may notice changes in hydration and texture earlier, while other outcomes may take longer to become apparent.

There is currently no universally established treatment schedule or guaranteed timeline for results. Your practitioner will discuss the expected course of treatment and appropriate review appointments during your consultation.

Are There Any Side Effects or Downtime?

Polynucleotide injections are minimally invasive, but they carry potential risks and side effects, as do other injectable aesthetic procedures.

Common temporary effects may include:

• Small raised bumps or papules at the injection sites.
• Redness and swelling.
• Mild bruising.
• Tenderness or discomfort.
• Temporary itching.

These effects often settle over a few days, although recovery varies depending on the treatment area, product and individual.

Less common but potentially more serious complications can occur with injectable treatments. These may include infection, allergic reactions and other injection-related complications. Your practitioner will explain the relevant risks, precautions and aftercare before treatment.

If you have a known fish or seafood allergy, tell your practitioner before your appointment so that the ingredients and suitability of the specific product can be checked.

Who Is Suitable for Polynucleotide Treatment?

Polynucleotide skin rejuvenation may be suitable for adults who wish to address early signs of skin ageing, fine lines, dullness or changes in skin texture and elasticity.

It may appeal to people seeking gradual improvements in skin quality without adding significant facial volume.

However, it is not suitable for everyone. Your practitioner will review your medical history, current skin condition, allergies and any relevant contraindications before recommending treatment.

Treatment may need to be postponed or avoided in certain circumstances, including:

• Pregnancy or breastfeeding.
• Active infection or inflammation at the intended injection site.
• Known hypersensitivity to the product or its ingredients.
• Other medical circumstances or contraindications specific to the selected product.

A consultation is required to establish whether treatment is appropriate for you.

Polynucleotides vs Dermal Fillers: What's the Difference?

Although both treatments involve injections, they have different purposes.