Cryotherapy is a relatively low-risk procedure. Cryopen® delivers N2O directly to the lesion, and not the healthy surrounding tissue. Cryopen® is both CE and FDA registered.


Cryopen® Therapy is relatively low risk. There are a few side effects that may occur as a result of treatment, including: • Pigmentary changes (hypopigmentation and hyperpigmentation) • Nerve damage (particularly in areas where nerves lie close to the surface of the skin, on fingers, wrist, area behind the ear) • Shards of frozen ice (minor shards of frozen ice may blow out, that will thaw on contact with healthy skin) • Hair follicle damage and permanent alopecia (especially when treating lesions on sites with coarse terminal hair) Discuss any concerns with your clinician.


Repeated short freezing cycles of 3 to 6 seconds at two-week intervals are recommended if you have a darker skin type.


A follow up visit is recommended after 2 to 4 weeks to confirm that all pathological tissue has disappeared or if a follow up treatment is necessary.


There will be a pain sensation similar to a ballpoint pen being pushed onto the skin when the nitrous oxide reaches the bottom of the lesion. There might be a little residual stinging for a few minutes after treatment. Occasionally a blister might form and persist for a few hours.


The penetration rate of freezing with the Cryopen® is approximately 1mm per 5 seconds, with a maximum freezing depth of 3 to 6mm depending on the used applicator. The duration of the treatment time will depend on the surface area and the thickness of the tissue being treated. Upon the clinical evaluation of the thickness of the lesion, the operator will choose an application time from 1 to 30 seconds.


Skin, skin tags, age spots, warts, actinic keratosis, verruca’s, Milia, cherry angiomas and other benign skin imperfections.


There are no limitations on activity except to protect the area from damage or abrasion. Swimming and showering is not a problem.


Most small common warts will respond to a single treatment. However, certain types and very deep ones can be very difficult to remove and may require more than one treatment.


This does not normally occur. Darkening or lightening of the skin may occur temporarily. Both generally last for a few months. The pigment change is more common in darker skin types.