Only qualified doctors or nurses administer the injections. These medical professionals inject small amounts of dermal filler directly into the skin with an ultra-fine needle. After cleansing the area to be treated, a numbing cream will be applied so there is minimal discomfort. The dermal filler is then administered to plump up the skin and smooth lines and wrinkles. If the lips or facial contours are treated, the filler restores lost volume, giving the lips or face a more shapely, fuller, fresher appearance.